Multiple sclerosis (MS) is a chronic disease of the central nervous system. MS disrupts the flow of information between the brain and the body, which can cause a range of symptoms that adversely affect daily life. According to the National Multiple Sclerosis Society (NMSS), nearly one million people are living with MS in the United States. Globally, that number is estimated to exceed 2.8 million.

If MS is a concern for you or your family, the following information may provide greater insight into the illness.

What occurs with MS?

The NMSS states that in MS, the immune system mistakenly attacks myelin, the protective sheath that covers nerve fibers. This damage begins as communication problems in the central nervous system, but can progress to permanent damage or deterioration of the nerves themselves. Current statistics show that MS is at least three times more common in women than in men, suggesting that hormones or a genetic factor may come into play.

Additionally, the disease is prevalent in regions farther from the equator, leading researchers to hypothesize a link between vitamin D deficiency and disease development. In 2015, scientists demonstrated a clear link between low vitamin D and MS. They found that people with naturally lower vitamin D levels were more likely to develop MS. Researchers in Oxford have also discovered that vitamin D may affect the behavior of a gene linked to MS. However, there currently is no evidence that high vitamin D levels reduce the risk of developing MS, although the Mayo Clinic reports studies have shown that taking 400 IU or more of vitamin D a day lowers the risk of MS in women.

Types of MS

MS can manifest in different forms. The most common is Relapsing-Remitting MS (RRMS). This is characterized by discrete attacks of new or worsening neurologic symptoms, followed by periods of partial or complete recovery. Many RRMS cases may eventually transition to Secondary Progressive MS (SPMS), which Cedars-Sinai says is marked by a gradual, steady worsening of neurological and physical disability. A smaller percentage of people are diagnosed with Primary Progressive MS (PPMS), where symptoms worsen steadily from the start without early relapses or remissions, says the Cleveland Clinic.

Symptoms of MS

Symptoms of MS can vary widely depending on the location of nerve damage, but typically include fatigue, difficulty walking or loss of balance, blurred vision or pain with eye movement (optic neuritis), and cognitive changes.

Look ahead

Doctors generally use MRI, blood tests, optical imaging of the nerves in the eye, and potentially a lumbar puncture to diagnose MS. Currently, there is no cure for MS. Treatment tends to focus on disease-modifying therapies that can slow the progression of worsening symptoms. Physical therapy and medications to manage additional symptoms may also be prescribed.

One can expect a normal life expectancy with MS, as only in very rare cases is MS fatal, advises the Cleveland Clinic. A care team will help a person through the MS journey to prevent complications and improve quality of life.