By Annette Pinder

Adnan Siddiqui is a neurosurgeon, UB Medical School Professor, Director of UB’s Canon Stroke and Vascular Research Center (CSVRC), Vice-Chairman of UB Neurosurgery (UBNS), Director of Neurosurgical Stroke Service at Kaleida Health’s Gates Vascular Institute (GVI), and CEO and Chief Medical Officer of the Jacobs Institute (JI).

At UBNS, Dr. Siddiqui treats patients, who require minimally invasive surgery for acute ischemic stroke, brain aneurysms and arteriovenous malformations, and open surgery for brain and skull base tumors. He has 500 peer reviewed publications, over 50 chapters, nearly 27,000 citations, and made over 200 presentations at national and international conferences. He has also designed and served as principal investigator for multiple major funded multi-site national and international clinical trials. His efforts, alongside Dr. Elad Levy and UBNS faculty have contributed to UBNS’ ranking 7th in academic impact in North America by the Journal of Neurosurgery.

“I grew up in Pakistan, knowing my father wanted me to become an accountant like him. When a catastrophic car accident and spinal cord injury took my younger brother’s life, and rendered my sister comatose, I committed to providing different answers than the ones we received from their treating neurosurgeons,” said Dr. Siddiqui.

After receiving his medical degree from Aga Khan University, the most prestigious medical school in Pakistan, Dr. Siddiqui left for the US, home to the best neurosurgical training in the world. He earned a PhD in Neuroscience from University of Rochester to better understand brain injury and ways to improve healing. He completed his neurosurgical residency at SUNY Upstate Medical University and obtained Fellowships in Interventional Neuroradiology, Cerebrovascular Surgery, and Neurocritical Care from Philadelphia’s Thomas Jefferson University. He is a Fellow of the American Association of Neurological Surgeons, American College of Surgeons, and the American Heart Association, and a member of the Society of Neurological Surgeons and Academy of Neurological Surgeons, organizations comprised of global leaders focused on advancing neurosurgical education and research.

Dr. Siddiqui attributes the success of JI, GVI, and CSVRC at the UB Clinical and Translational Research Center to Founder, L. Nelson “Nick” Hopkins, MD, explaining, “Dr. Hopkins’ imagined and succeeded in bringing clinicians, scientists, and engineers together to address the primary cause of death and disability in human beings throughout the world and here in Western New York which has one of the highest rates of vascular disease in the country.”

Regarding how his career has evolved within and beyond the operating room, he says, “I was always interested in a blend of research incorporating science into surgery.” Reflecting upon what drives him, he says, “While operating on patients, I am always aware of the limitations we face and driven to develop new methods for treating the devastating effects of stroke, aneurysms, brain, and head and neck cancer. Like many of my UBNS colleagues, I feel driven to constantly push myself toward changing how we treat patients and improving patient outcomes. My daily practice involves leading science efforts at CSVRC with distinguished researchers, while leading clinical research studies at GVI with the best medical technologies available in the world.”

At JI, Dr. Siddiqui focuses on entrepreneurship, working with startups and inventors to develop technologies that transform ideas into reality to advance the care of patients with vascular diseases. To accomplish this, he focuses on building strong and trusting relationships with fellow neurosurgeons, neurologists, neuroradiologists, scientists, engineers, regulatory officers, and industry.

Regarding his personal achievements, Dr. Siddiqui says, “I am profoundly indebted to my mentors for shaping my career as a dual-trained cerebrovascular surgeon, clinician scientist, and entrepreneur.” When he isn’t at JI or tending to patients at GVI, he loves spending time with his wife and three children. To stay healthy, he follows a healthy diet and rides Peloton, saying that biking may have saved his life.

There is so much happening in medicine, science, and technology. As for what’s next, Dr. Siddiqui says, “Just give us a few years and the whole world will recognize JI and the ecosystem being developed around the Buffalo Niagara Medical Campus. Worldwide, those focused on vascular disease recognize us for changing vascular medicine and developing Buffalo as the med-tech hub of the future.”

JI, a non-profit 501(c)(3) organization based on philanthropy, depends on donations to bring the best ideas from discovery to clinical practice. Learn more at, where you can also donate to further life-changing research.